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Traceless chemical ligations from O-acyl serine sites |
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| Authors: | El Khatib Mirna Elagawany Mohamed Jabeen Farukh Todadze Ekaterina Bol'shakov Oleg Oliferenko Alexander Khelashvili Levan el-Feky Said A Asiri Abdullah Katritzky Alan R |
| Affiliation: | Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. |
| Abstract: | Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation. |
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