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Facilitated transport of 5-aminosalicylic acid through bulk liquid membrane |
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| Authors: | Ionut Zaharia Hassan Y Aboul-Enein Ioana Diaconu Elena Ruse Andrei A Bunaciu Gheoghe Nechifor |
| Institution: | 1. Department of Analytical Chemistry, University Politehnica Bucharest, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania 2. Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12311, Egypt 3. SCIENT—Research Center for Instrumental Analysis, (S.C. CROMATEC_PLUS S.R.L.), Bucharest, Romania |
| Abstract: | This paper describes the experimental results obtained at the transport of 5-aminosalicylic acid (5ASA) through agitated bulk liquid membrane, using Aliquat 336, as carrier, dissolved in a chloroform membrane. The influence of 5-aminosalicylic acid concentration in the feed source, HCl concentration in the stripping phase and carrier (Aliquat 336) concentration in the membrane were investigated. The optimal pH condition of feed source was established based on the speciation diagram of 5-aminosalicylic acid. The assessment of the transport process was performed by determining the kinetic parameters—mass transfer coefficient and entrance and exist flow in and out of the chloroform membrane. |
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