| Abstract: | The mechanism of the addition of nucleophiles to alkyne-derivatives 1 having both push- and pull-groups yielding Michael-adducts is investigated. The rate of the second-orderreaction increases (a) with increasing nucleophilic character of the amine and alcohol respectively, (b) with increasing electrophilic character of the alkyne-derivatives 1 , and (c) with increasing solvent polarity. These results support as rate-determining step an attack of the nucleophile at C(3) of the alkyne-derivatives. |
