Desoxaphomin,das erste [13]Cytochalasan,ein möglicher biogenetischer Vorläufer der 24-Oxa-[14]cytochalasane |
| |
Authors: | Michael Binder Christoph Tamm |
| |
Abstract: | From cultures of a Phoma species (strain S 298) the hitherto unknown metabolite deoxaphomine has been isolated. On the basis of the spectral data, structure 1 of the (7S, 16R, 20R)-7,20-dihydroxy-16-methyl-10-phenyl-13]cytochalasa-6(12),13t,21t-triene-1,23-dione is assigned to deoxaphomine. This structure is confirmed by the chemical degradation of 1 , yielding the products 4 and 6 which are identical with derivatives of phomine ( 2 )((7S,16R,20R)-7,20-dihydroxy-16-methyl-10-phenyl-24-oxa-14]cytochalasa-6(12), 13t,21t-triene-1,23-dione) and cytohalasin D ( 8 ) ((7S,16S,18R,21R)-21-acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-11]sytochalasa-6(12),13t,19t-triene-1,17-dione). Deoxaphomine ( 1 ) is a potential biogenetic precursor of the 24-oxa-14]cytochalasans. Preliminary results of the biological activity of deoxaphomine are reported. |
| |
Keywords: | |
|
|