| Abstract: | Information is given on the influence of fluorene and fluorenone derivatives on the melting point of thymus DNA and their interferon-inducing activity. The substances investigated form complexes predominantly with the AT pairs of DNA. A comparative electro-phoretic study of complexes of the substances investigated and of ethidium bromide has shown that the fluorene and fluorenone derivatives do not intercalate into the DNA double helix. The change in the melting point of DNA correlates with the chemical structure of the compounds investigated and depends on the volume of the substituent on the nitrogen atom of the side chain.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 404–409, May–June, 1988. |
