Tasumatrols P – T,Five New Taxoids from Taxus sumatrana |
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| Authors: | Ya‐Ching Shen Yun‐Sheng Lin Shaw‐Man Hsu Ashraf?Taha Khalil Shih‐Sheng Wang Ching‐Te Chien Yao‐Haur Kuo Chang‐Hung Chou |
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| Institution: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China, (tel: +886‐2‐23123456, ext. 2226;2. fax: +886‐2‐23919098);3. Department of Marine Biotechnology and Resources, National Sun Yat‐sen University, Kaohsiung 804, Taiwan, Republic of China;4. Institute of Biology, National Sun Yat‐sen University, Taiwan, Republic of China;5. Division of Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan, Republic of China;6. National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China |
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| Abstract: | The phytochemical investigation of the more polar fractions from the leaves and twigs of Taxus sumatrana (Taxaceae) afforded five new taxane diterpene esters, tasumatrols P–T ( 1 – 5 ) possessing an 11(15→1),11(10→9)‐diabeotaxane skeleton. Compounds 1, 4 , and 5 contain an α‐hydroxy group at C(14), while 3 has no OH group at either C(13) or C(14). Compound 2 is a natural 4,5‐acetonide derivative, while 4 has an unusual spiro‐connected 2‐hydroxy‐2‐phenyl‐1,3‐dioxolane ring. Ten known taxoids, were also isolated in the course of the chromatographic fractionation. Five additional new O‐acetyl derivatives 3a, 4a, 4b, 5a , and 5b were prepared from the taxanes 3 – 5 . The structures of all new compounds were established on the basis of their spectroscopic analyses. Compound 1 showed mild cytotoxic activity against human Hela and Daoy tumor cells. |
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| Keywords: | Taxus sumatrana Tasumatrols P – T Taxoids Cytotoxic activity |
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