One‐Pot Three‐Component Synthesis of α‐Amino Nitriles Catalyzed by 2,4,6‐Trichloro‐1,3,5‐triazine (Cyanuric Acid) |
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| Authors: | Biswanath Das Rathod Aravind Kumar Ponnaboina Thirupathi |
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| Affiliation: | 1. Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500 007, India, (phone: +91‐40‐7193434;2. fax: +91‐40‐7160512) |
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| Abstract: | ![]()
A simple and efficient method has been developed for the synthesis of α‐amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature. |
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| Keywords: | Cyanuric acid Nitriles, α ‐amino Trimethylsilyl cyanide 1,3,5‐Triazine, 2,4,6‐trichloro‐ One‐pot three‐component synthesis Strecker‐type reaction |
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