Four New Podocarpane‐Type Trinorditerpenes from Aleurites moluccana |
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| Authors: | Hai‐Yang Liu Shi‐Jin Li Yi Zhao Wei Ni Xiao‐Jiang Hao Jun‐Zhu Li Yan Hua Bai‐Bo Xie Chen Qing Chang‐Xiang Chen |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China, (phone: +86‐871‐5223245;2. fax: +86‐871‐5223246);3. Southwest Forest College, Kunming 650224, P.?R. China;4. Yunnan Key Laboratory of Pharmacology for Natural Products Research, Kunming Medical College, Kunming 650031, P.?R. China, (phone: +86‐871‐5310307;5. fax: +86‐871‐5316884) |
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| Abstract: | Four new podocarpane‐type trinorditerpenenes, (5β,10α)‐12,13‐dihydroxypodocarpa‐8,11,13‐trien‐3‐one ( 1 ), (5β,10α)‐12‐hydroxy‐13‐methoxypodocarpa‐8,11,13‐trien‐3‐one ( 2 ), (5β,10α)‐13‐hydroxy‐12‐methoxypodocarpa‐8,11,13‐trien‐3‐one ( 3 ), and (3α,5β,10α)‐13‐methoxypodocarpa‐8,11,13‐triene‐3,12‐diol ( 4 ), together with four known diterpenes, 12‐hydroxy‐13‐methylpodocarpa‐8,11,13‐trien‐3‐one ( 5 ), spruceanol ( 6 ), ent‐3α‐hydroxypimara‐8(14),15‐dien‐12‐one ( 7 ), and ent‐3β,14α‐hydroxypimara‐7,9(11),15‐triene‐12‐one ( 8 ), were isolated from the twigs and leaves of Aleurites moluccana. Their structures were elucidated by means of comprehensive spectroscopic analyses, including NMR and MS. Except 8 , all compounds were evaluated for their cytotoxicity; compound 4 exhibited moderate inhibitory activity against Raji cells with an IC50 value of 4.24 μg/ml. |
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| Keywords: | Aleurites moluccana Podocarpanes Trinorditerpenes Cytotoxic activity |
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