Cytotoxic Withaphysalins from Physalis minima |
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| Authors: | Lei Ma Xian‐Wen Gan Qing‐Ping He Hai‐Yun Bai Mohammad Arfan Feng‐Chang Lou Li‐Hong Hu |
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| Institution: | 1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, P.?R. China;2. Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai, 201203, P.?R. China, (phone: +86‐21‐50272221;3. fax: +86‐21‐50272221);4. Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan |
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| Abstract: | A novel withanolide, withaphysalin P ( 1 ) with a nine‐membered ring, and six other new withaphysalins, 2 – 7 , together with the three known withaphysalins 8 – 10 were isolated from Physalis minima L. The structures were deduced by means of spectroscopic analyses, and that of withaphysalin P ( 1 ) was confirmed by a single‐crystal X‐ray diffraction analysis. Plausible biosynthetic pathways were postulated (Scheme 1). All compounds were tested for their antiproliferative activities toward the human colorectal‐carcinoma HCT‐116 cells and human nonsmall‐cell lung‐cancer NCI‐H460 cells (Table 4). Compounds 1 – 3, 7 – 10, 7a , and 7b displayed moderate cytotoxic activity against the two human cancer cell lines. |
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| Keywords: | Physalis minima Withaphysalins Cytotoxic activity X‐Ray crystallography |
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