Synthesis and Structure of 2‐Substituted Thieno[3′,2′:5,6]pyrido[4,3‐d]pyrimidin‐4(3H)‐one Derivatives |
| |
Authors: | Jian‐Chao Liu Hong‐Wu He Ming‐Wu Ding |
| |
Institution: | Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, P.?R. China, (phone: +86(27)67865406) |
| |
Abstract: | A series of new 2‐substituted 3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno3′,2′: 5,6]pyrido4,3‐d]pyrimidin‐4(3H)‐ones 8 were synthesized via an aza‐Wittig reaction. Phosphoranylideneamino derivatives 6a or 6b reacted with 4‐chlorophenyl isocyanate to give carbodiimide derivatives 7a or 7b , respectively, which were further treated with amines or phenols to give compounds 8 in the presence of a catalytic amount of EtONa or K2CO3. The structure of 2‐(4‐chlorophenoxy)‐3‐(4‐chlorophenyl)‐5,8,9‐trimethylthieno3′,2′: 5,6]pyrido4,3‐d]pyrimidin‐4(3H)‐one ( 8j ) was comfirmed by X‐ray analysis. |
| |
Keywords: | Pyrido[4 3‐d]pyrimidin‐4(3H)‐one Aza‐Wittig reaction |
|
|