Carboxylic acid–pyridine supramolecular heterocatemer in a co-crystal |
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| Authors: | P Sudhakar R Srivijaya BR Sreekanth PK Jayanthi Peddy Vishweshwar Moses J Babu K Vyas Javed Iqbal |
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| Institution: | aDepartment of Analytical Research, Discovery Research, Dr. Reddy’s Laboratories Ltd.,1 Miyapur, Hyderabad 500049, Andhra Pradesh, India;bDepartment of Medicinal Chemistry, Discovery Research, Dr. Reddy’s Laboratories Ltd., Miyapur, Hyderabad 500049, Andhra Pradesh, India |
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| Abstract: | Robustness of carboxylic acid–pyridine supramolecular heterosynthon was examined in three 1:2 binary co-crystals of 4,4′-bipyridine with monocarboxylic acids, (4,4′-bipyridine)·(dl-hydroxyphenylacetic acid)2, 1; (4,4′-bipyridine)0.5·(4-bromonaphthalene-1-carboxylic acid), 2 and (4,4′-bipyridine)0.5·(4-methylbenzoic acid), 3. All the three co-crystals form “two-component supermolecules” (consisting of one molecule of 4,4′-bipyridine and two molecules of the relevant carboxylic acid) stabilized through carboxylic acid–pyridine heterosynthons. Co-crystals 1 and 2 exhibits the expected carboxylic acid–pyridine dimer (heterodimer I) whereas co-crystal 3 forms a novel carboxylic acid–pyridine catemer (heterocatemer II). |
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| Keywords: | 4 4′ -Bipyridine Co-crystal Crystal engineering Supramolecular chemistry Supramolecular heterosynthon |
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