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Catalyst economy. Part 2: Sequential metathesis—Kharasch sequences using the Grubbs metathesis catalysts |
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| Authors: | Chris D Edlin Peter Quayle |
| Institution: | a Medicinal Chemistry 1, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts. SG1 2NY, UK b School of Chemistry, The University of Manchester, Manchester M13 9PL, UK |
| Abstract: | Sequential ring-closing metathesis (RCM)-Kharasch cyclizations are promoted by the Grubbs metathesis catalysts and provide rapid access to bicyclic lactones and lactams. |
| Keywords: | Grubbs Metathesis Kharasch Cyclization Tandem ATRC RCM Metathesis Radical |
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