Synthesis of fused imidazo-pyridine and -azepine derivatives by sequential van Leusen/Heck reactions |
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| Authors: | Xenia Beebe Vijaya Gracias Stevan W Djuric |
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| Institution: | Scaffold-Oriented Synthesis, Medicinal Chemistry Technologies, Abbott Laboratories, R4CP, AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA |
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| Abstract: | Fused imidazo-pyridine and -azepine derivatives were synthesized using a sequential van Leusen/intramolecular Heck protocol. The combination of a multicomponent reaction followed by an intramolecular carbon-carbon bond forming reaction generates heterocycles of significant molecular complexity from readily available starting materials in just two steps. |
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