Rhamnosylation of lignans by a Streptomyces strain |
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Authors: | Patrik Eklund Toni Holmström Rainer Sjöholm |
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Institution: | a Department of Organic Chemistry, Process Chemistry Centre, Åbo Akademi University, Piispankatu 8, FIN-20500 Turku, Finland b Lividans Ltd, Lemminkäisenkatu 30, FIN-20520 Turku, Finland |
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Abstract: | Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. |
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