Phosphine-catalyzed enantioselective [3+2] annulations of 2,3-butadienoates with imines |
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Authors: | Ludovic Jean |
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Institution: | Institut de Chimie des Substances Naturelles—CNRS UPR 2301, 1, avenue de la Terrasse, 91198 Gif-sur-Yvette, France |
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Abstract: | The first systematic screening of chiral phosphines in the cycloaddition reaction between 2,3-butadienoates and arylimines has led to the identification of fairly efficient catalysts. 2-Aryl-3-pyrrolines have been obtained with enantiomeric excesses up to 64%. In one instance, the enantiomeric excess could be increased to 91% ee by combining the enantioselective cyclization reaction with a crystallization step. |
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Keywords: | [3+2] Cycloadditions Enantioselective organocatalysis Phosphines 3-Pyrrolines |
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