Synthetic studies toward the immunosuppressant FR901483. Facile construction of the azatricyclic skeleton |
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| Authors: | Suvi TM Simila |
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| Institution: | Department of Chemistry and Biochemistry, The University of Texas, Austin, TX 78712, USA |
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| Abstract: | A concise synthesis of the azatricyclic core structure of FR901483, a potent immunosuppressant, has been accomplished. The key elements of the approach involve a nucleophilic addition to an acyl iminium ion, a ring closing metathesis and a lactone-lactam rearrangement to provide the tricyclic structure. |
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| Keywords: | Additions to N-acyl iminium ions Ring closing metathesis Lactone-lactam rearrangement |
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