A convenient semicarbazide resin for the solid-phase synthesis of peptide ketones and aldehydes |
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Authors: | Jesús Vázquez |
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Institution: | Barcelona Biomedical Research Institute, Barcelona Science Park and Department of Organic Chemistry, University of Barcelona, E-08028 Barcelona, Spain |
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Abstract: | Use of a semicarbazide resin for the solid-phase preparation of peptide ketones and aldehyde led to optimal results in terms of both purity of the final product and overall yield. This resin was prepared without complication by activation of the commercial available aminomethyl polystyrene with CDI at room temperature, followed by treatment with tert-butyl carbazate. Furthermore, the TNBSA colorimetric assay has been adapted for checking the incorporation of the carbonyl moiety onto hydrazine-based resins. |
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Keywords: | Amino ketones Ketone synthesis Combinatorial chemistry High-throughput synthesis Solid-phase peptide synthesis |
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