|
|||||
|
|
Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines |
|
| Authors: | Vassilios N. Kourafalos,Emmanuel Mikros,Nicole Pouli,Jaromí r Marek |
| Affiliation: | a Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis, 15771 Zografou, Greece b Laboratory of Functional Genomics and Proteomics, Faculty of Science, Masaryk University, Kamenice 5/A2 Brno, CZ-62500, Czech Republic c National Center for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5/A4 Brno, CZ-62500, Czech Republic |
| Abstract: | A number of 7-substituted pyrazolo[3,4-c]pyridine derivatives have been synthesized in order to investigate the N1-N2 tautomerism within this class of biologically interesting compounds. Tautomeric equilibrium has been studied using NMR 13C, 15N chemical shifts and heteronuclear 1H-15N and 1H-13C spin-spin couplings, in conjunction with X-ray crystallography. The N1 tautomer predominates in DMF solution in all the compounds tested. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |