A novel and green protocol for two-carbon homologation: a direct amino acid/K2CO3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides |
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| Authors: | Dhevalapally B Ramachary M Kishor K Ramakumar |
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| Institution: | School of Chemistry, University of Hyderabad, Central University (P.O.), Hyderabad 500 046, India |
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| Abstract: | A novel and green approach for the two-carbon homologation of aldehydes using amino acid catalysis has been developed and further extended to the generation of pharmaceutically active cyano-esters via four-component reactions in one-pot. |
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| Keywords: | Amino acids Hantzsch ester Multi-component reactions Organocatalysis Two-carbon homologation |
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