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A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine |
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| Authors: | Daniel L Comins Emilie D Smith |
| Institution: | Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA |
| Abstract: | The anti-Parkinson’s agent SIB-1508Y was prepared in six steps from (S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at C-5 of a 1,4-dihydronicotine intermediate. |
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