Total synthesis and absolute stereochemistry of plakortone E |
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| Authors: | Megumi Akiyama |
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| Affiliation: | Department of Biological Chemistry, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan |
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| Abstract: | The absolute stereochemistry of plakortone E, a cytotoxic metabolite of the Caribbean sponge, was established to be 1, by the synthesis of the racemic C-8 epimer (±)-2 and then of (−)-1 itself, which was identical with the natural compound. |
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| Keywords: | Plakortone E Alkylidenecarbene C-H insertion Absolute stereochemistry |
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