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CAN-mediated oxidative cleavage of 4-aryl-3,4-dihydroxypiperidines |
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| Authors: | Meng-Yang Chang Chun-Yu Lin Chun-Li Pai |
| Affiliation: | a Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung 811, Taiwan b Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan |
| Abstract: | A CAN-mediated oxidative cleavage of 4-aryl-3,4-dihydroxypiperidines 2Aa-Be to β-amino carbonyl compounds 3Aa-Be and 4Aa-Be in different ratios is described. This facile strategy was also used to synthesize racemic fluoxetine (5). |
| Keywords: | 4-Hydroxypiperidine 4-Aryl-3,4-dihydroxypiperidines β-Amino carbonyl compounds Cerium ammonium nitrate Fluoxetine |
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