Investigations of Imidazoles. 101. Synthesis of 2,3-Dihydroimidazo[1,2-a]pyrimidine from 2-Aminopyrimidine |
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| Authors: | P M Kochergin I A Mazur G K Rogul'chenko E V Aleksandrova B E Mandrichenko |
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| Institution: | (1) Center for the Chemistry of Medicinals. All Russian Chemical-Pharmaceutical Science Research Institute, 119815 Moscow;(2) Zaporozhe State Medicinal University, 330074 Zaporozhe, Ukraine |
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| Abstract: | Two novel preparative methods have been developed for the synthesis of 2,3-dihydroimidazo1,2-a]pyrimidine from 2-aminopyrimidine. These are the reaction with 1,2-dibromoethane and also the reaction with ethylene chloro(bromo)hydrin, subsequent treatment of 1- -hydroxyethyl-2-imino-1,2-dihydropyrimidine with thionyl chloride, and cyclization of the intermediate 1--chloroethyl-2-imino-1,2-dihydropyrimidine in the presence of sodium hydroxide. |
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| Keywords: | 2-aminopyrimidine 1 2-dibromoethane dihydroimidazopyrimidine imidazole ethylene chloro(bromo)hydrin cyclization |
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