|
|||||
|
|
An efficient and simple synthesis of α-amino phosphonates as ‘drug like’ molecules catalyzed by silica-supported perchloric acid (HClO4–SiO2) |
|
| Authors: | Malek Taher Maghsoodlou Sayyed Mostafa Habibi-Khorassani Reza Heydari Nourallah Hazeri Seyed Sajad Sajadikhah Mohsen Rostamizadeh |
| Institution: | Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran |
| Abstract: | An efficient and direct protocol is described for the preparation of α-amino phosphonates derivatives by employing a multi-component, one-pot condensation reaction of aldehyde, amine and trialkyl phosphite in the presence of silica-supported perchloric acid (3 mol%) under solvent-free conditions. The thermal solvent-free green procedure offers advantages such as shorter reaction time, simple work-up, high yield, recovery and reusability of catalyst. |
| Keywords: | α-Amino phosphonates Silica supported perchloric acid Heterogeneous catalyst Multi-component Trialkyl phosphite |
| 本文献已被 ScienceDirect 等数据库收录！ | |