An efficient synthesis of styryl 1,3,4-thiadiazoles using Lawesson’s reagent and Propylphosphonic anhydride-precursors for bis heterocycles |
| |
Institution: | Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India |
| |
Abstract: | The compounds styryl 1,3,4-thiadiazoles were prepared adopting one and two step methodologies to optimize the yield of the products. The two-step methodology via benzohydrazide followed by treatment with Lawesson’s reagent in the presence of Propylphosphonic anhydride and triethylamine produced styryl 1,3,4-thiadiazoles in excellent yields. The olefin moiety in these compounds is utilized to develop pyrazole and isoxazole rings by 1,3-dipolar cycloaddition methodology followed by oxidation. |
| |
Keywords: | Nitrile imine Nitrile oxide Manganese dioxide Pyrazolyl thiadiazole Isoxazolyl thiadiazole |
本文献已被 ScienceDirect 等数据库收录! |
|