The regioselective switch for amino-NHC mediated C-H activation of benzimidazole via Ni-Al synergistic catalysis |
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| Authors: | Shih Wei-Chun Chen Wen-Ching Lai Ying-Chieh Yu Ming-Shiuan Ho Jhao-Jhe Yap Glenn P A Ong Tiow-Gan |
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| Affiliation: | Institute of Chemistry, Academia Sinica, Nangang, Taipei, Taiwan, Republic of China. |
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| Abstract: | ![]()
We have disclosed a new mode of a chemically regioselective switch for C-H bond functionalization of benzimidazole derivatives via a cooperative effect invoked by Ni-Al bimetallic catalysis to create a steric requirement for obtaining the linear product of styrene insertion. Yet, excluding the AlMe(3) cocatalyst switches the reaction toward branch selectivity. |
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