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| 聚酯／聚酸酐共混体系的降解和药物释放行为 | |
| 引用本文： | 唐爱军 贺晓晖. 聚酯／聚酸酐共混体系的降解和药物释放行为[J]. 高分子学报, 1996, 0(4): 486-489 |
| 作者姓名： | 唐爱军 贺晓晖 |
| 作者单位： | 北京大学化学系 |
| 摘 要： | 聚酯／聚酸酐共混体系的降解和药物释放行为唐爱军，贺晓晖，李福绵（北京大学化学系北京１００８７１）关键词聚癸二酸，聚乳酸，聚己内酯，降解行为，药物释放行为聚酸酐，特别是脂肪类聚酸酥由于其化学价键的水解活泼性，是一类快速生物降解材料．由于聚酸团的水解机制... |
| 关 键 词： | 聚癸二酸，聚乳酸，聚己内酯，降解行为，药物释放行为 |
BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM |
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| TANG Aijun, HE Xiaohui, LI Fumian. BIODEGRADATION AND DRUG RELEASE BEHAVIOR OF A NOVEL POLYESTER /POLYANHYDRIDE BLENDS SYSTEM[J]. Acta Polymerica Sinica, 1996, 0(4): 486-489 | |
| Authors: | TANG Aijun HE Xiaohui LI Fumian |
| Abstract: | Poly(sebacic anhydride) (PSA) was prepared from the mixed anhydride of diacid. PSA was blended with polylactone (PLA) and polycaprolactone (PCL) respectively. The blends were fabricated into film by solvent casting. Hydrolytic degradation and drug release experiments were carried out in 0.1 mol /1 phosphate buffer PH 7.4 at 37℃ by examining the changes in weight, molecular weight, DSCcurve. Indomethacinum and p-nitroauiline were used as model drugs. Samples with a higher portion of PSA showed higher degradation rate. Rate of release depended on the content of PSA and the properties of drug. All systems demonstrated burst releaseduring the first few days. |
| Keywords: | Poly(sebacic anhydride) Polycaprolactone Biodegradation Hydrolysis Drug release |
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