On the sites and mechanisms of alkylation in the nucleic acids |
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Authors: | Alberte Pullman Anne-Marie Armbruster |
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Affiliation: | (1) Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au C.N.R.S., 13, rue P. et M. Curie, F-75005 Paris, France |
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Abstract: | The intrinsic capacity (computed by ab initio molecular orbital techniques) of ethyl and methyl cations to bind to the anionic oxygens of the phosphate groups of the nucleic acids is found to be larger than their affinity for the carbonyl oxygens or for the nitrogens of the bases cytosine and guanine. Analysis of the components of the binding energies indicates that the preference of the ethyl cation for the oxygens of the phosphate or for those of the bases is due to different reasons. The results are discussed in connection with the available experimental observations. |
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Keywords: | Nucleic acids alkylation of /content/k2p3338q23943101/xxlarge8764.gif" alt=" sim" align=" MIDDLE" BORDER=" 0" > |
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