Synthetic studies on β-lactam antibiotics. VII. Mild removal of the benzyl ester protecting group with aluminum trichloride |
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| Authors: | Teruji Tsuji Takahiro Kataoka Mitsuru Yoshioka Yuji Sendo Yasuhiro Nishitani Shoichi Hirai Takashi Maeda Wataru Nagata |
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| Affiliation: | Shionogi Research Laboratory, Shionogi & Co., Ltd., Fukushima-ku, Osaka, 553 Japan |
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| Abstract: | ![]()
The benzyl ester protecting group in β-lactam derivatives can be cleanly removed by treatment with aluminum trichloride under mild conditions, preferably in the presence of anisole, to give the corresponding free acids in high yields. |
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