Stability of fluorenylemthoxycarbonylamino groups in peptide synthesis. Cleavage by hydrogenolysis and by dipolar aprotic solvents

$\text{N}$-Fluorenylmethoxycarbonyl derivatives of amines are unexpectedly cleaved by catalytic hydrogenation with t$\text{1}\text{2}$ 3–33 h. under various conditions. They are also cleaved on standing in the solvents dimethylformamide, dimethylacetamine, and $\text{N}$-methylpyrrolidone, but much more slowly.