Highly aminated mesoporous silica nanoparticles with cubic pore structure |
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Authors: | Suteewong Teeraporn Sai Hiroaki Cohen Roy Wang Suntao Bradbury Michelle Baird Barbara Gruner Sol M Wiesner Ulrich |
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Institution: | Departments of Materials Science and Engineering, Chemistry and Chemical Biology, and Physics, Cornell University, Ithaca, New York 14853, United States, Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States, and Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, New York 14853, United States. |
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Abstract: | Mesoporous silica with cubic symmetry has attracted interest from researchers for some time. Here, we present the room temperature synthesis of mesoporous silica nanoparticles possessing cubic Pm3?n symmetry with very high molar ratios (>50%) of 3-aminopropyl triethoxysilane. The synthesis is robust allowing, for example, co-condensation of organic dyes without loss of structure. By means of pore expander molecules, the pore size can be enlarged from 2.7 to 5 nm, while particle size decreases. Adding pore expander and co-condensing fluorescent dyes in the same synthesis reduces average particle size further down to 100 nm. After PEGylation, such fluorescent aminated mesoporous silica nanoparticles are spontaneously taken up by cells as demonstrated by fluorescence microscopy. |
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