Evaluation of 1-methyl-3,4-hydroxypyridinecarboxylic acids as possible bidentate chelating agents for iron(III): Metal–ligand solution chemistry |
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Authors: | Valerio B Di Marco Annalisa Dean Robert A Yokel Haitao Li G Giorgio Bombi |
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Institution: | 1. Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy;2. College of Pharmacy, 511C Pharmacy Building, University of Kentucky Medical Center, Rose Street, Lexington, KY 40536-0082, USA |
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Abstract: | The chemical interactions of 1-methyl-3-hydroxy-4-pyridinecarboxylic acid (1M3H4P) and 1-methyl-4-hydroxy-3-pyridinecarboxylic acid (1M4H3P) with Fe(III) were investigated in aqueous 0.6 m (Na)Cl at 25 °C by means of potentiometric titrations and UV–Vis spectrophotometry. A large number of complexes were formed in solution with stoichiometry FeLxHy, x = 1, 2, 3 and y = 0, −1, −2. In view of a possible application to Fe(III) chelation therapy, the efficiencies of the ligands to chelate the metal ion were evaluated in vitro at physiological pH. 1M3H4P and 1M4H3P show a lower complexation efficiency with Fe(III) than that of other available chelators, but higher than that of their non-methylated analogs 3H4P and 4H3P. |
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Keywords: | Iron Carboxylate ligands Chelation therapy Potentiometry UV&ndash Vis Solution chemistry |
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