Thioquinomycins A-D,novel naphthothiophenediones from the marine-derived Streptomyces sp. SS17F |
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| Authors: | Dashan Zhang Yongjun Jiang Jiaqi Li Wanjing Ding Zhe Chen Zhongjun Ma |
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| Institution: | 1. Institute of Marine Biology, Ocean College, Zhejiang University, No. 1 Zheda Rd., Zhoushan 316021, PR China;2. Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, PR China;3. Ocean Academy, Zhejiang University, Zhoushan 316021, PR China |
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| Abstract: | Thioquinomycins A-D (1–4), four novel naphthothiophenediones were isolated from the rice-based medium of the marine-derived Streptomyces sp. SS17F. Their structures were elucidated by spectroscopic methods and HRESIMS data. The absolute configurations of all the compounds were elucidated by X-ray diffraction analysis, ECD and Mosher's method combined with 19F-NMR. Compounds 1–4 showed moderate cytotoxicity against NCI-H1975 with IC50 values from 17.5 to 50?μM. In addition, compounds 1–4 also exhibited inhibitory activities against PKCα and ROCK2 protein kinase. |
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| Keywords: | Thioquinomycins A-D X-ray diffraction Cytotoxicity Kinase inhibitory activities |
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