Acyclic stereoselection. 15. Sequential aldol-claisen as a method for 1,5-stereoselection. Total synthesis of the vitamin-E side chain |
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| Authors: | Clayton H. Heathcock Esa T. Jarvi |
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| Affiliation: | Department of Chemistry, University of California Berkeley, California 94720 USA |
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| Abstract: | ![]()
Alcohol1, the side chain of α-tocopherol, has been synthesized in a stereoselective route involving an aldol condensation-Claisen rearrangement sequence. The synthesis require 11 steps and produces1in 17% overall yield. A complementary sequence employing reagent14provides isomer18. |
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