Enaminone as Building Blocks in Organic Chemistry: A Novel Route to Polyfunctionally 2‐Substituted 5,6,7,8‐Tetrahydronaphthalenes and Their Antiviral Evaluation |
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| Authors: | Nehal A. Hamdy Waled M. El‐Senousy Issa M. I. Fakhr |
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| Affiliation: | 1. Applied Organic Chemistry Department, National Research Centre, , Dokki 12622, Cairo, Egypt;2. Enteric Viruses Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, , Dokki 12622, Cairo, Egypt |
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| Abstract: | The enaminone 2 reacts with different reagents to afford anilino, aroylpyridine, 1,3,5‐tri‐tetrahydronaphthoyl‐benzene, pyridine, 2,3,6‐trisubstituted pyridines, pyrazole, pyrido[1,2‐a]benzimidazole, and hydrazone derivatives 4 , 6 , 8 , 9 , 11 , 13 , 15 , 17 , 20 , and 21 . The antiviral evaluation of some selected new products showed promising antiviral activity against human adenovirus 7 and human rotavirus Wa strain. |
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