Synthesis and Biological Activity of New Chiral N‐Acylsulfonamide Bis‐oxazolidin‐2‐ones |
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| Authors: | Radia Bouasla Hadjira Berredjem Malika Berredjem Malika Ibrahim‐Oualid Assia Allaoui Marc Lecouvey Nour‐Eddine Aouf |
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| Institution: | 1. Laboratoire de Chimie Organique Appliquée, Groupe de Chimie Bioorganique, Université Badji Mokhtar, , Annaba, BP 12 Algeria;2. Laboratoire de Toxicologie Cellulaire, Universite Badji Mokhtar, , Annaba, BP 12 Algeria;3. Institut des Sciences Moléculaires de Marseille, UMR 7313 CNRS and Université d'Aix Marseille, Faculté des Sciences et Techniques de Saint Jér?me, Avenue Escadrille Normandie‐Niemen, , 13397 Marseille Cedex 20, France;4. Laboratoire de Chimie Bioorganique et Bionanomatériaux, CSPBAT, FRE 3043 CNRS, Université Paris 13, , Bobigny Cedex, France |
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| Abstract: | A new series of chiral 5‐substituted bis‐oxazolidinones containing an acylsulfonamide moiety has been synthesized starting from chlorosulfonyl isocyanate, (l )‐ethyl lactate, and oxazolidin‐2‐ones. All the reactions were conducted at ambient temperature, and the N‐acylsulfonamide bis‐oxazolidin‐2‐ones were obtained with high yields within 2 h. Some of the newly synthesized compounds were evaluated in vitro against the virulent strain RH of Toxoplasma gondii and the human lymphocytes, and showed promising results. |
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