Microwave‐assisted Aqueous Multicomponent Reaction: Facile Synthesis of Polyfunctionalized Indoline‐spiro Fused Pyran Derivatives |
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Authors: | Qiong Wu Hui Feng Dong‐Dong Guo Mian‐Shuai Yi Xing‐Han Wang Bo Jiang Shu‐Jiang Tu |
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Institution: | 1. School of Chemistry and Chemical Engineering and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, , Xuzhou, Jiangsu, 221116 People's Republic of China;2. The Center of Evidence of Chongqing Police Bureau, , Jiangbei District, Chongqing, China |
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Abstract: | A green and highly efficient method for the synthesis of polyfunctionalized indoline‐spiro fused pyran derivatives has been established. This reaction was conducted by reacting readily available and inexpensive starting materials, such as isatins, cyclic‐1,3‐dicarbonyl compounds, and malononitrile in aqueous media without any catalysts under microwave irradiation. The present green synthesis shows fascinating properties such as the use of water as the reaction solution, concise one‐pot conditions, short reaction periods (8–14 min), and easy purifications. The synthesis could also set a good example to GAP (Group‐Assistant‐Purification) chemistry in which purification via chromatography can be avoided and the pure products can be easily acquired only by washing the crude products with 95% EtOH. |
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