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Photochemical Properties and Activity of Water‐Soluble Polymer/C60 Nanohybrids for Photodynamic Therapy |
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| Authors: | Marie Hurtgen Antoine Debuigne Maryse Hoebeke Catherine Passirani Nolwenn Lautram Ange Mouithys‐Mickalad Pierre‐Henri Guelluy Christine Jérôme Christophe Detrembleur |
| Affiliation: | 1. Department of Chemistry, Center for Education and Research on Macromolecules (CERM), B6A, University of Liège, 4000 Liège, Belgium;2. Laboratory of Biomedical Spectroscopy, B5A, University of Liège, 4000 Liège, Belgium;3. INSERM U 646, University of Angers, Rue A. Boquel 10, 49100 Angers, France;4. Center for Oxygen Research and Development, B6A, University of Liège, 4000 Liège, Belgium |
| Abstract: | Water‐soluble star‐like poly(vinyl alcohol)/C60 and poly{[poly(ethylene glycol) acrylate]‐co‐(vinyl acetate)}/C60 nanohybrids are prepared by grafting macroradicals onto C60 and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) of the polymeric arms respectively impact the photodynamic activity and the stealthiness of the nanohybrids. The advantages of both nanohybrids are encountered in a third one, poly[(N‐vinylpyrrolidone)‐co‐(vinyl acetate)]/C60, which has linear grafts without hydroxyl groups, and shows a better photodynamic activity.  |
| Keywords: | biological applications of polymers cobalt‐mediated radical polymerizations fullerenes graft copolymers photodynamic therapy |