An Efficient Two‐Step Synthesis of New 5‐Substituted‐1H‐tetrazoles of Biological Interest |
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| Authors: | Nilo Zanatta Fabio M da Silva Andreia M P W da Silva Estefania da C Aquino Helio G Bonacorso Marcos A P Martins |
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| Institution: | Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, , 97.105‐900 Santa Maria, RS, Brazil |
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| Abstract: | A simple procedure for the synthesis and characterization of new 3‐alkoxy‐3‐(1H‐tetrazol‐5‐yl)propionic acids and 2‐(1H‐tetrazol‐5‐yl)tetrahydrofuran‐ and ‐(1H‐tetrazol‐5‐yl)‐2H‐pyran‐3‐carboxylic acids from the 2 + 3] cycloaddition reactions between the nitrile group of β‐cyanocarboxylic acids with sodium azide in the presence of zinc chloride is described. The tetrazolic acids were isolated in moderate to good yields and are structurally analogous to succinic acid. |
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