An efficient synthesis of 2,3‐dihydroquinazolin‐4(1H)‐one derivatives under catalyst‐free and solvent‐free conditions |
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| Authors: | Lijiu Gao Honglou Ji Liangce Rong Dan Tang Yunyun Zha Yanhui Shi Shujiang Tu |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu 221116, P.R. China;2. Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou Normal University, Xuzhou, Jiangsu 221116, P.R. China |
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| Abstract: | A simple, efficient and convenient one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐one derivatives under solvent‐free and catalyst‐free conditions by the reaction of aromatic aldehydes, isatoic anhydride, and ammonium acetate was reported. The advantages of this protocol include short reaction time, mild reaction conditions, easy work‐up, high yields, and environmental friendliness. J. Heterocyclic Chem., (2011). |
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