Synthesis and antimicrobial activity of some heterocyclic 2,6‐bis(substituted)‐1,3,4‐thiadiazolo‐, oxadiazolo‐, and oxathiazolidino‐pyridine derivatives from 2,6‐pyridine dicarboxylic acid dihydrazide |
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| Authors: | Said A. S. Ghozlan Mohammed A. Al‐Omar Abd El‐Galil E. Amr Korany A. Ali Ahmed A. Abd El‐Wahab |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt;2. Department of Pharmaceutical Chemistry, College Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;3. Department of Applied Organic Chemistry, National Research Centre, Dokki, Cairo, Egypt |
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| Abstract: | ![]()
In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 10a , 10b , 11 , 11a , 11b , 12 , 12a , 12b , 13 , 13a , 13b , 14 , 15 based on N2′,N6′‐diphenylthiosemi‐carbazide pyridine‐2,6‐dicarbohydrazide 2 , which has been obtained from the corresponding dihydrazide 1 . The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011). |
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