Xestospongienols A–L,Brominated Acetylenic Acids from the Chinese Marine Sponge Xestospongia testudinaria |
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| Authors: | Dong Liu Jing Xu Wei Jiang Zhiwei Deng Nicole J de?Voogd Peter Proksch Wenhan Lin |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P.?R. China (phone: +86‐10‐82806188);2. Analytical and Testing Center, Beijing Normal University, Beijing 100075, P.?R. China;3. National Museum of Natural History, P.O. Box 9517, NL‐2300 Leiden;4. Institute of Pharmaceutical Biology and Biotechnology, Heinrich‐Heine University, D‐40225 Düsseldorf |
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| Abstract: | Chemical examination of the Chinese marine sponge Xestospongia testudinaria resulted in the isolation and characterization of twelve new brominated acetylenic acids, namely xestospongienols A–L ( 1a – 1d, 2a – 2d , and 3a – 3d ), together with the known analog 4 . The structures of xestospongienols A–L were determined on the basis of 1D‐ and 2D‐NMR, IR, and MS analysis in association with the modified Mosher method. The structural patterns are characteristic of brominated unbranched C16‐alkyl chains containing polyene and acetylene moieties. |
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| Keywords: | Xestospongia testudinaria Xestospongienols A – L Acetylenic acids brominated Marine sponges |
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