Synthesis and α‐glucosidase inhibitory,DPPH scavenging activity of substituted 2‐oxo‐2H‐chromen‐7‐yl‐dihydrogen phosphate derivatives |
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| Authors: | J Ashok Kumar Ashok K Tiwari AZehra Ali R Ranga Rao B China Raju |
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| Institution: | 1. Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500 607, India;2. Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad‐500 607, India |
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| Abstract: | Series of phosphorylated coumarin derivatives ( 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j ) were synthesized by Pechmann condensation, phosphorylation, and debenzylation reactions in very good yields. Thus, synthesized compounds ( 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j ) were evaluated for their α‐glucosidase and 1,1‐diphenyl‐2‐picrylhydrazyl scavenging activities; few compounds showed moderate to good activity. J. Heterocyclic Chem., 00 , 00 (2011). |
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