Efficient Synthesis of 2‐(2‐Aminophenyl)‐2,3‐dihydropyridin‐4(1H)‐ones Based on a Cyclization/Ring Cleavage Procedure |
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| Authors: | Vahuni Karapetyan Satenik Mkrtchyan Gnuni Karapetyan Alexander Villinger Ashot Saghiyan Tariel V. Ghochikyan Peter Langer |
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| Affiliation: | 1. Institut für Chemie, Universit?t Rostock, Albert‐Einstein‐Strasse 3a, D‐18059 Rostock;2. Faculty of Chemistry, Yerevan State University, Alex Manoogian 1, 0025 Yerevan, Armenia;3. CJSC Scientific Research Institute of Biotechnology, Gyurjyan Str. 14, 0056, Yerevan, Armenia;4. Leibniz‐Institut für Katalyse e. V. an der Universit?t, Rostock, Albert‐Einstein‐Str. 29a, D‐18059 Rostock |
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| Abstract: | (Benzyloxycarbonyl)‐protected 3,4‐benzo‐7‐hydroxy‐2,9‐diazabicyclo[3.3.1]non‐7‐enes were prepared by one‐pot cyclizations of 1,3‐bis(silyl enol ethers) with quinazolines. Subsequent hydrogenation resulted in one‐pot deprotection and rearrangement to give 2‐(2‐aminophenyl)‐2,3‐dihydropyridin‐4(1H)‐ones. |
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| Keywords: | Quinazolines Pyridin‐4(1H)‐ones Silyl enol ethers X‐Ray crystallography |
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