Two New Prenylated Xanthones from the Pericarp of Garcinia mangostana (Mangosteen) |
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| Authors: | Xiaojun Zhou Riming Huang Jing Hao Huijuan Huang Manqin Fu Zhifang Xu Yongmei Zhou Xu‐E Li Samuel X Qiu Bin Wang |
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| Institution: | 1. Department of Pharmacy, Medical College, Nanchang University, Nanchang 330006, P.?R. China;2. Program for Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P.?R. China (phone/fax: +86‐20‐37081190);3. Guangdong Provincial Key Lab of Biotechnology for Plant Development, South China Normal University, Guangzhou 510631, P.?R. China |
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| Abstract: | Two new prenylated xanthones (=9H‐xanthen‐9‐ones), garcimangosxanthones D ( 1 ) and E ( 2 ), together with the six known xanthones 3 – 8 , were isolated from the pericarp of Garcinia mangostana. Their structures were determined by analysis of their spectroscopic data. All of the isolated compounds were biologically evaluated for their in vitro cytotoxic activity against A549, Hep‐G2, and MCF‐7 human‐cancer cell lines and antioxidant activity. Compound 1 exhibited moderate cytotoxicity against Hep‐G2 (IC50=19.2 μM ) and weak cytotoxicity against MCF‐7 (IC50=62.8 μM ) cell lines, and compound 2 showed moderate cytotoxicity against A549, Hep‐G2, and MCF‐7 cell lines with IC50 values of 12.5–20.0 μM (Table 2). Both compounds 1 and 2 demonstrated a weak antioxidant activity with ferric reducing antioxidant power (FRAP) values of 41±7 and 130±4 μmol/g, respectively (Table 3). |
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| Keywords: | Garcinia mangostana Garcimangosxanthones D and E Cytotoxic activity Antioxidant activity |
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