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Microwave‐Assisted Cross‐Coupling for the Construction of Diaryl Sulfides |
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| Authors: | Chen‐Ming Tan Grace Shiahuy Chen Chien‐Shu Chen Ji‐Wang Chern |
| Institution: | 1. School of Pharmacy, National Taiwan University, Taipei 100, Taiwan, R.O.C.;2. Department of Applied Chemistry, Providence University, Shalu 433, Taiwan, R.O.C.;3. School of Pharmacy, China Medical University, Taichung 404, Taiwan, R.O.C.;4. Department of Life Science, National Taiwan University, Taipei 100, Taiwan, R.O.C. |
| Abstract: | The construction of diaryl sulfides through the cross‐coupling of aryl iodides and thiols in microwave heating is described. By using this method, a variety of diaryl sulfides can be prepared in a mild condition and in high yields. Deactivated 4‐nitrothiophenol was effective to afford the product in 94% yield. Sterically hindered ortho‐substituted aryl iodides or thiophenols provided diaryl sulfides effectively by this microwave‐assisted coupling reaction. |
| Keywords: | Aryl iodide Diaryl sulfide Ligand Copper iodide Cross‐coupling Microwave heating |