Bismuth triflate–L(−)‐proline catalyzed synthesis of chiral 2,5‐diaryl‐2,3‐dihydropyrano[2,3‐b]quinolin‐4‐ones |
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| Authors: | Nitu Mahajan Surrinder Koul Tej K Razdan |
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| Institution: | 1. Department of Chemistry, University of Jammu, Ambedkar Road, Jammu 180006, India;2. Indian Institute of Integrated Medicine, Canal Road, Jammu 180006, India |
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| Abstract: | The synthesis of chiral (2R) 2,5‐diaryl‐2,3‐dihydropyrano2,3‐b]quinolin‐4‐ones, was achieved, at ambient temperature, by the reaction of 3‐acetyl‐4‐aryl‐carbostyril and an aldehyde, in the presence of bismuth triflate–L(?)‐proline complex, formed in situ. The products were obtained in 62–78% yield with high enantioselectivity (72–96% ee). J. Heterocyclic Chem., (2011). |
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