Polycyclic N‐heterocyclic compounds. Part 66: Synthesis of N‐[2‐([1,2,4]oxadiazol‐5‐yl)cyclopenten‐1‐yl]formamide oximes and their evaluation as inhibitors of platelet aggregation |
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| Authors: | Kensuke Okuda Ying‐Xue Zhang Hiromi Ohtomo Takashi Hirota Kenji Sasaki |
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| Institution: | 1. Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, Gifu 501‐1196, Japan;2. Faculty of Pharmaceutical Sciences, Okayama University, Kita‐ku, Okayama 700‐8530, Japan |
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| Abstract: | N‐2‐(1,2,4]Oxadiazol‐5‐yl)cyclopenten‐1‐yl]formamide oximes were synthesized by fusion of (6,7‐dihydro‐5H‐cyclopenta1,2‐d]pyrimidin‐4‐yl)amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products for anti‐platelet aggregation activity revealed that certain of them showed promising inhibitory effect on arachidonic acid‐induced platelet aggregation. J. Heterocyclic Chem., (2011). |
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