Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine |
| |
Authors: | Mustapha Zaher Corinne Ravelet Isabelle Baussanne Anne Ravel Catherine Grosset Jean-Luc Décout Eric Peyrin |
| |
Institution: | (1) Département de Pharmacochimie Moléculaire UMR 5063 CNRS, Institut de Chimie Moléculaire de Grenoble FR 2607, Université Grenoble I (Joseph Fourier), UFR de Pharmacie, 38041 Grenoble cedex 9, France |
| |
Abstract: | In this paper, we describe the preparation and the evaluation of a porous graphitic carbon (PGC) column coated with a new
dinaphthyl derivative of neamine for chiral ligand-exchange (LE) chromatography. It was shown that the graphitic surface/dinaphthyl
anchor system efficiently (1.15 μmol/m2) and stably (three months of intensive use) adsorbs the neamine template onto the chromatographic support. The resulting
coated PGC stationary phase showed appreciable LE-based enantioselective properties towards several native amino acids.
Chromatographic separation of methionine enantiomers using a dinaphtyl neamine-based ligand-exchange chiral stationary phase |
| |
Keywords: | Porous graphitic carbon Chiral separation Amino acid enantiomers Ligand-exchange chromatography Neamine derivative |
本文献已被 PubMed SpringerLink 等数据库收录! |