The analysis of thiocarbamides by gas chromatography/negative-ion chemical-ionization mass spectrometry. |
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| Authors: | D G Watson C D Bates G G Skellern R Mairs S Martin |
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| Affiliation: | Department of Pharmacy, University of Strathclyde, Glasgow, UK. |
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| Abstract: | Thiocarbamides were converted to their di-N-pentafluorobenzyl (PFB) derivatives and analysed by gas chromatography/negative-ion chemical-ionization mass spectrometry with methane as reagent gas. The PFB derivatives of the 2-thiouracils gave mass spectra in which the ion current was carried largely by an ion arising from [M-PFB]-. The derivative was used in the determination of the uptake and metabolism of thiocarbamides by cultures of melanoma cells. |
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